Founded in 1975 as the all Union Research Institute of Applied Enzimology, currently, the Institute of Biotechnology is mainly involved in research and training in the fields of biotechnology and molecular biology, including research and development of recombinant biomedical proteins, genetic and molecular studies of restriction modification phenomenon, developing of viruses diagnostics, epigenetic study of small RNA, drug design and synthesis, bioinformatics.
FRAMEWORK 7 PROGRAMMEDevelopment of novel antiviral drugs against Influenza (FLUCURE). 2010-2014. Dr. G. Žvirblis.
Towards construction of a comprehensive map of amyloid-ligand interactions:
(-)-Epigallocatechin 3-Gallate and insulin amyloid (EGCG+INSULIN=). 2011-2015. Dr. V. Smirnovas.
Integrated Microfluidic System for Long Term Cell Cultivation, Monitoring and Analysis. BioCellChip, 2012-2015. Dr. L. Mažutis.
NATIONAL INSTITUTE OF HEALTH
Approaches for genomic mapping of 5-hydroxymethylcytosine a novel epigenetic mark in mammalian DNA. 2010-2012. Prof. S. Klimašauskas.
Direct single nucleotide mapping of genomic CpG marks. 2013-2015. Prof. S. Klimašauskas.
PROJECTS OF THE EUROPEAN SOCIAL FUND UNDER GLOBAL GRANT MEASURE
Molecular tools for epigenomics and RNomics. 2011-2015. Prof. Habil. Dr. S. Klimašauskas.
Structure and molecular mechanisms of bacterial antivirus defence systems. 2011-2015. Prof. Dr. V. Šikšnys.
Novel chimeric proteins with antiviral activity. 2012-2015. Dr. A. Žvirblienė.
Design of selective carbonic anhydrase, Hsp90, and Hsp70 inhibitors and investigation of their anticancer properties. 2012-2015. Dr. D. Matulis.
The use of genome-wide analysis for engineering of new yeast strains with improved heterologous expression. 2012-2015. Dr. R. Slibinskas.
Exploring flavones as universal inhibitors of amyloid-like fibril formation. 2012-2015. Dr. V. Smirnovas.
Making use of large-scale biological data for the development of a new method to assess protein models and for studying DNA replication and repair systems in bacteria and viruses. 2013-2015. Dr. Č. Venclovas.
Protein ligand binding volume and its application in drug design. 2014-2016. dr. V.Petrauskas.
The role of Cas1 ir Cas2 proteins in adaptation mechanism of CRISPR-Cas systems. 2014-2016. dr. G.Gasiūnas.Bayesian nonparametrics for detection of distant protein homology. 2013-2015. dr. M. Margelevičius.
Genomic mapping of covalently tagged CpG sites. 2013-2015. dr. E. Kriukienė.
Synthesis of Schmallenberg virus proteins and their application for diagnostic means. 2013-2015. prof. K. Sasnauskas
Investigation of RNA interference in bacteria. 2013-2015. dr. G. Tamulaitis.
Structural and functional studies of restriction enzyme family. 2013-2015. dr. G. Tamulaitienė.Expansion of the Crystallography Open Database (COD) and Statistical Analysis of Crystal Structures. 2013-2015. dr. S. Gražulis
High-throughput screening of antibody-secreting cells using droplet-based microfluidics. 2012-2014. Dr. L. Mažutis
Function of a molecular motor in atypical restriction-modification system. 2012-2014. Dr. M. Zaremba
Structure and function of 5-methyl and 5-hydroxymethylcytosine-directed restriction endonucleases. 2012-2014. Dr. G. Sasnauskas
Studies on the biogenesis molecular mechanism of non coding RNAs in plants. 2012-2014. Dr. G. Vilkaitis
Looking for the origins of mammalian prion 'strains'. 2012-2014. Dr. V. Smirnovas
A Universal Method for Recombinant Synthesis of Selenoproteins. 2012-2014. dr. R.RakauskaitėStudies on the mechanism of the cytolytic activity of the bacterial toxin vaginolysin. 2012-2014. dr. M.Plečkaitytė
Carbonic anhidrase hCA XII as a potential marker for cancer cells. 2012-2014. Dr. D. Matulis
Splicing factors and their regulated miRNA as cancer biomarkers for gastrointestinal system. 2012-2014. Dr. A. Kanopka
Molecular mechanisms in Alzheimer's disease. 2012-2014. Dr. A.Žvirblienė
Studies on allergic diseases genetic and environmental risk factors in the Lithuanian newborn cohort. 2012-2014. Dr. A.Žvirblienė
Interspecific hybrids of orchard plant - a novel source of anthocyanins. 2011-2014. Dr. R.Ražanskas
Expression analysis of anthocyanin biosynthesis genes in horticultural plants. 2012-2015. Dr. V. KazanavičiūtėSWISS-LT
Signalling control of pathogen induced plant immunity. 2013-2016. dr. I.Meškienė.
NATIONAL COMPLEX PROGRAMME
Biotechnology and Biopharmacy: fundamental and applied research.2012-2015. prof. K.Sasnauskas.