Founded in 1975 as the all Union Research Institute of Applied Enzimology, currently,  the Institute of Biotechnology is mainly involved in research and training in the fields of biotechnology and molecular biology, including research and development of recombinant biomedical proteins, genetic and molecular studies of restriction modification phenomenon, developing of viruses diagnostics, epigenetic study of small RNA, drug design and synthesis, bioinformatics.

Current Grants



Development of novel antiviral drugs against Influenza (FLUCURE). 2010-2014. Dr. G. Žvirblis.

Towards construction of a comprehensive map of amyloid-ligand interactions:
(-)-Epigallocatechin 3-Gallate and insulin amyloid (EGCG+INSULIN=). 2011-2015. Dr. V. Smirnovas.

Integrated Microfluidic System for Long Term Cell Cultivation, Monitoring and Analysis. BioCellChip, 2012-2015. Dr. L. Mažutis.


Approaches for genomic mapping of 5-hydroxymethylcytosine a novel epigenetic mark in mammalian DNA. 2010-2012. Prof. S. Klimašauskas.

Direct single nucleotide mapping of genomic CpG marks. 2013-2015. Prof. S. Klimašauskas.


Molecular tools for epigenomics and RNomics. 2011-2015. Prof. Habil. Dr. S. Klimašauskas.

Structure and molecular mechanisms of bacterial antivirus defence systems. 2011-2015. Prof. Dr. V. Šikšnys.

Novel chimeric proteins with antiviral activity. 2012-2015. Dr. A. Žvirblienė.

Design of selective carbonic anhydrase, Hsp90, and Hsp70 inhibitors and investigation of their anticancer properties. 2012-2015. Dr. D. Matulis.

The use of genome-wide analysis for engineering of new yeast strains with improved heterologous expression. 2012-2015. Dr. R. Slibinskas.

Exploring flavones as universal inhibitors of amyloid-like fibril formation.  2012-2015. Dr. V. Smirnovas.

Making use of large-scale biological data for the development of a new method to assess protein models and for studying DNA replication and repair systems in bacteria and viruses. 2013-2015. Dr. Č. Venclovas.


Signalling components in stem cells. 2014-2016. dr. A.Schweighofer.

Protein ligand binding volume and its application in drug design. 2014-2016. dr. V.Petrauskas.

The role of Cas1 ir Cas2 proteins in adaptation mechanism of CRISPR-Cas systems. 2014-2016.  dr. G.Gasiūnas.

Bayesian nonparametrics for detection of distant protein homology. 2013-2015. dr. M. Margelevičius.

Genomic mapping of covalently tagged CpG sites. 2013-2015. dr. E. Kriukienė.

Synthesis of Schmallenberg virus proteins and their application for diagnostic means. 2013-2015. prof. K. Sasnauskas

Investigation of RNA interference in bacteria. 2013-2015. dr. G. Tamulaitis.

Structural and functional studies of restriction enzyme family. 2013-2015. dr. G. Tamulaitienė.

Expansion of the Crystallography Open Database (COD) and Statistical Analysis of Crystal Structures. 2013-2015. dr. S. Gražulis

Development of recombinant antibodies against carbonic anhydrase. 2012-2014. Dr. A. Žvirblienė

High-throughput screening of antibody-secreting cells using droplet-based microfluidics. 2012-2014. Dr. L. Mažutis

Function of a molecular motor in atypical restriction-modification system. 2012-2014. Dr. M. Zaremba

Structure and function of 5-methyl and 5-hydroxymethylcytosine-directed restriction endonucleases. 2012-2014. Dr. G. Sasnauskas

Studies on the biogenesis molecular mechanism of non coding RNAs in plants. 2012-2014. Dr. G. Vilkaitis

Looking for the origins of mammalian prion 'strains'. 2012-2014. Dr. V. Smirnovas

A Universal Method for Recombinant Synthesis of Selenoproteins. 2012-2014. dr. R.Rakauskaitė

Studies on the mechanism of the cytolytic activity of the bacterial toxin vaginolysin. 2012-2014. dr. M.Plečkaitytė

Carbonic anhidrase hCA XII as a potential marker for cancer cells. 2012-2014. Dr. D. Matulis

Splicing factors and their regulated miRNA as cancer biomarkers for gastrointestinal system. 2012-2014. Dr. A. Kanopka

Molecular mechanisms in Alzheimer's disease. 2012-2014. Dr. A.Žvirblienė

Studies on allergic diseases genetic and environmental risk factors in the Lithuanian newborn cohort. 2012-2014. Dr. A.Žvirblienė

Interspecific hybrids of orchard plant - a novel source of anthocyanins. 2011-2014. Dr. R.Ražanskas

Expression analysis of anthocyanin biosynthesis genes in horticultural plants. 2012-2015. Dr. V. Kazanavičiūtė


Directed evolution of computer designed enzymes using droplet  based microfluidics. 2012-2016. prof. A.Janulaitis

Signalling control  of pathogen induced plant immunity. 2013-2016. dr. I.Meškienė.


Biotechnology and Biopharmacy: fundamental and applied research.2012-2015. prof. K.Sasnauskas.