Founded in 1975 as the all Union Research Institute of Applied Enzimology, currently,  the Institute of Biotechnology is mainly involved in research and training in the fields of biotechnology and molecular biology, including research and development of recombinant biomedical proteins, genetic and molecular studies of restriction modification phenomenon, developing of viruses diagnostics, epigenetic study of small RNA, drug design and synthesis, bioinformatics.

Laboratory of Bioinformatics • Models

Spausdinti
  • Molecular model of the OB-domain of E. coli DNA polymerase III alpha subunit (polIII_alpha_OB_model.pdb)

    • Reference: McCauley MJ, Shokri L, Sefcikova J, Venclovas Č, Beuning PJ, Williams M. (2008) Distinct double- and single-stranded DNA binding of E. coli replicative DNA polymerase III alpha subunit. ACS Chem Biol, 3:577-587. [PubMed]
  • Molecular models for type II restriction enzymes TstI-SR, PpiI-SR and the TstI-PpiI chimera (TstI-SR_model.pdb, PpiI-SR_model.pdb, Tst-PpiTRD1_G1006L_model.pdb)

    • Reference: Jurėnaitė-Urbanavičienė S, Šerkšnaitė J, Kriukienė E, Giedrienė J, Venclovas Č, Lubys A. (2007) Generation of DNA cleavage specificities of type II restriction endonucleases by reassortment of target recognition domains. Proc Natl Acad Sci USA, 104:10358-10363. [PubMed]