Founded in 1975 as the all Union Research Institute of Applied Enzimology, currently, the Institute of Biotechnology is mainly involved in research and training in the fields of biotechnology and molecular biology, including research and development of recombinant biomedical proteins, genetic and molecular studies of restriction modification phenomenon, developing of viruses diagnostics, epigenetic study of small RNA, drug design and synthesis, bioinformatics.
2003-2012D. Matulis, Cikotiene I., Kazlauskas E., Matuliene J. 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof. EP 2268626 B1.2012-02-01.
Žvirblienė A., Gedvilaitė A., Ulrich R., Sasnauskas K. Process for the production of monoclonal antibodies using chimeric VLPs. US 7919314 (B2).
Sherneck Siegfried, Sasnauskas Kęstutis, Ulrich Rainer. Method of producing virus-like particles on the basis of polyoma viruses. EP 1030923 B1.
Janulaitis. A., Stankevicius K., Lubys A., Markauskas A. Strand-specific polynucleotide nickases. EP 1 176 204 B1;. US. 6 867 028 B2
Becher D. Siekstele R., Bartkeviciute D., Sasnauskas K. Doehner L., Salim S. Regulatory sequences and expression cassettes for yeast, especially for Kluyveromyces. US 7132522.
Zvirbliene A., Gedvilaite A., Ulrich R.; Sasnauskas K. Process for the production of monoclonal antibodies. US 7919314 (B2).
Matulis D., Dudutienė V., Matulienė J., Mištinaitė L. Benzimidazo[1,2-C][1,2,3]thiadiazol-7-sulfonamides as inhibitors of carbonic anhydrase and the intermediates for production thereof. EP2054420E. Weinhold, C. Dalhoff, S. Klimašauskas, G. Lukinavičius. S-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases. US 8,008,007. 2011-08-30