Founded in 1975 as an independent research institution, now part of Vilnius University, the Institute of Biotechnology strives to maintain the high standards of excellence in scientific endeavour, research training and technological advance with its main focus in a broadly defined field of molecular biotechnology including nucleic acid and protein technologies, bioinformatics, molecular diagnostics, drug design, next generation epigenomic and gene editing technologies. The Institute provides an interface between advanced education, basic research and technological development for the economic and social benefit of Lithuania.

 

Patents

Spausdinti

Klimasauskas S., Liutkeviciute Z., Kriukiene E. Derivatization of biomolecules by covalent  coupling of non-cofactor compounds using methyltransferases. EP 2414528 B1, D60 2010 015 838.1, 2014/05/07; US 8822146B2, 2014/09/2

Klimasauskas S., Liutkeviciute Z., Kriukiene E. Conversion of alphahydroxyalkylated residues in biomolecules using methyltransferases. US 8889352 (B2); 2014/11/18

Weinhold E., Dalhoff C., Klimašauskas S., Lukinavičius G. New S-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases. JP 129120 B2. 2013-01-23

Matulis D., Cikotiene I., Kazlauskas E., Matuliene J. 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof. US 831413220. 2012-12-20

D. Matulis, Cikotiene I., Kazlauskas E., Matuliene J. 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof. EP 2268626 B1. 2012-02-01

Matulis D., Dudutienė V., Matulienė J., Mištinaitė L. Benzimidazo[1,2-C][1,2,3]thiadiazol-7-sulfonamides as inhibitors of carbonic anhydrase and   the intermediates for production thereof.  EP2054420. 2011-06-22

E. Weinhold, C. Dalhoff, S. Klimašauskas, G. Lukinavičius. New S-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases. US 8,008,007. 2011‑08‑30

Žvirblienė A., Gedvilaitė A., Ulrich R., Sasnauskas K. Process for the production of monoclonal antibodies using chimeric VLPs. US 7919314 B2. 2011-04-05

Weinhold E., Dalhoff C., Klimašauskas S., Lukinavičius G. S-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases.  EP1874790. 2010-08-18

Becher D. Siekstele R., Bartkeviciute D., Sasnauskas K. Doehner L., Salim S. Regulatory sequences and expression cassettes for yeast, especially for Kluyveromyces. US 7132522. 2006‑11‑07

Janulaitis A.,  Stankevicius K., Lubys A., Markauskas A. Strand-specific polynucleotide nickases. EP 1 176 204 B1, 2005/01/06;. US 6 867 028 B2, 2005-03-15

Sherneck Siegfried, Sasnauskas Kęstutis, Ulrich Rainer. Method of producing virus-like particles on the basis of polyoma viruses. EP 1030923 B1. 2005-02-09

PATENT APPLICATIONS

Klimašauskas S., Rakauskaitė R., Masevičius V. Production of selenoproteins. PCT/LT2014/000009.

Siksnys V., Kazlauskiene M., Tamulaitis G. Programmable RNA shredding by the Type III-A CRSIPR-Cas system of Streptococcus thermophilus, U.S. Patent Application Serial No. 62/046, 384

Mažutis L. Microfluidic system and method for production of biopolymer-based droplets and particles. PCT/LT2014/000013. 2014/12/03

Klimasauskas S., Kriukiene E., Urbanaviciute G., Petronis A., Khare T., Wang S. Analysis of methylation sites. EP 2594651 A1. 2013-05-22

Klimasauskas S., Kriukiene E., Urbanaviciute G., Petronis A., Khare T., Wang S. Analysis of methylation sites. US, 20130130922 (A1). 2013-05-23

Klimašauskas S., Staševskij Z. Nucleic acid production and sequence analysis. US 20130130249 A1. 2013‑05-23

Klimašauskas S., Staševskij Z. Nucleic acid production and sequence analysis. PCT/WO 2013/072515 A1. 2013-05-23

Klimašauskas S., Vilkaitis G., Plotnikova A. Analysis of small RNA. UK patent application GB1210756.1 2012-06-15

Siksnys V., Gasiunas G., Karvelis T. RNA-directed DNA cleavage by the Cas9-crRNA complex from CRISPR3/Cas immune system of Streptococcus thermophilus. PCT/US2013/033106

D. Matulis, V. Dudutienė, A. Zubrienė. Fluorinated benzenesulfonamides as inhibitors of Carbonic Anhydrase. PCT/LT2012/000007. 2012-10-30.

Klimašauskas S., Staševskij Z. Nucleic acid production and sequence analysis.  Patento paraiška GB1119903.1  2011-11-17

Klimašauskas S., Kriukienė E., Urbanavičiūtė G., Petronis A., Khare T., Wang S.-C. Analysis of methylation sites.  Patento paraiška GB1119904.9. 2011-11-17

Zvirbliene Aurelija, Kucinskaite-Kodze Indre, Pleckaityte Milda, Zvirblis Gintautas. Monoclonal Antibodies Against Vaginolysin. EP2398823 A1. 2011-12-28

Klimašauskas S., Liutkevičiūtė Z., Kriukienė E., Petronis A.,  Khare T., Wang S.C. Analysis of hydroxymethylated nucleic acids. GB1012390.9