Biotechnologijos institutas yra  mokslinių tyrimų institucija, siekianti užtikrinti valstybės pažangą sparčiai besivystančiose gyvybės mokslų ir biotechnologijų srityse, plėtoti tarptautinio lygio molekulinės biotechnologijos tyrimus, skatinti tarpdisciplininius tyrimus bei mokslo ir verslo bendradarbiavimą

2005-2010 m. publikacijos

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  1. Sasnauskas, G., Zakrys, L., Zaremba, M., Cosstick, R., Gaynor, J. W., Halford, S. E. & Siksnys, V., A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site. Nucleic Acids Res, 2010, vol. 38, 2399-2410. (PDF)
  2. Zaremba, M., Owsicka, A., Tamulaitis, G., Sasnauskas, G., Shlyakhtenko, L. S., Lushnikov, A. Y., Lyubchenko, Y. L., Laurens, N., van den Broek, B., Wuite, G. J. L. & Siksnys, V., DNA synapsis through transient tetramerization triggers cleavage by Ecl18kI restriction enzyme. Nucleic Acids Res, 2010. (PDF)
  3. Zaremba, M. & Siksnys, V., Molecular scissors under light control. Proc Natl Acad Sci U S A, 2010, vol. 107, 1259-1260. (PDF)
  4. Gilmore, J. L., Suzuki, Y., Tamulaitis, G., Siksnys, V., Takeyasu, K. & Lyubchenko, Y. L., Single-molecule dynamics of the DNA-EcoRII protein complexes revealed with high-speed atomic force microscopy. Biochemistry, 2009, vol. 48, 10492-10498. (PDF)
  5. Golovenko, D., Manakova, E., Tamulaitiene, G., Grazulis, S. & Siksnys, V., Structural mechanisms for the 5'-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII. Nucleic Acids Res, 2009, vol. 37, 6613-6624. (PDF)
  6. Ibryashkina, E. M., Sasnauskas, G., Solonin, A. S., Zakharova, M. V. & Siksnys, V., Oligomeric structure diversity within the GIY-YIG nuclease family. J Mol Biol, 2009, vol. 387, 10-16. (PDF)
  7. Neely, R. K., Tamulaitis, G., Chen, K., Kubala, M., Siksnys, V. & Jones, A. C., Time-resolved fluorescence studies of nucleotide flipping by restriction enzymes. Nucleic Acids Res, 2009, vol. 37, 6859-6870. (PDF)
  8. Gasiunas, G., Sasnauskas, G., Tamulaitis, G., Urbanke, C., Razaniene, D. & Siksnys, V., Tetrameric restriction enzymes: expansion to the GIY-YIG nuclease family. Nucleic Acids Res, 2008, vol. 36, 938-949. (PDF)
  9. Sasnauskas, G., Connolly, B. A., Halford, S. E. & Siksnys, V., Template-directed addition of nucleosides to DNA by the BfiI restriction enzyme. Nucleic Acids Res, 2008, vol. 36, 3969-3977. (PDF)
  10. Sukackaite, R., Grazulis, S., Bochtler, M. & Siksnys, V., The recognition domain of the BpuJI restriction endonuclease in complex with cognate DNA at 1.3-A resolution. J Mol Biol, 2008, vol. 378, 1084-1093. (PDF)
  11. Szczepanowski, R. H., Carpenter, M. A., Czapinska, H., Zaremba, M., Tamulaitis, G., Siksnys, V., Bhagwat, A. S. & Bochtler, M., Central base pair flipping and discrimination by PspGI. Nucleic Acids Res, 2008, vol. 36, 6109-6117. (PDF)
  12. Tamulaitiene, G. & Siksnys, V., NotI is not boring. Structure, 2008, vol. 16, 497-498. (PDF)
  13. Tamulaitis, G., Zaremba, M., Szczepanowski, R. H., Bochtler, M. & Siksnys, V., How PspGI, catalytic domain of EcoRII and Ecl18kI acquire specificities for different DNA targets. Nucleic Acids Res, 2008, vol. 36, 6101-6108. (PDF)
  14. Kaus-Drobek, M., Czapinska, H., Sokołowska, M., Tamulaitis, G., Szczepanowski, R. H., Urbanke, C., Siksnys, V. & Bochtler, M., Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically. Nucleic Acids Res, 2007, vol. 35, 2035-2046. (PDF)
  15. Sasnauskas, G., Connolly, B. A., Halford, S. E. & Siksnys, V., Site-specific DNA transesterification catalyzed by a restriction enzyme. Proc Natl Acad Sci U S A, 2007, vol. 104, 2115-2120. (PDF)
  16. Shlyakhtenko, L. S., Gilmore, J., Portillo, A., Tamulaitis, G., Siksnys, V. & Lyubchenko, Y. L., Direct visualization of the EcoRII-DNA triple synaptic complex by atomic force microscopy. Biochemistry, 2007, vol. 46, 11128-11136. (PDF)
  17. Sokolowska, M., Kaus-Drobek, M., Czapinska, H., Tamulaitis, G., Siksnys, V. & Bochtler, M., Restriction endonucleases that resemble a component of the bacterial DNA repair machinery. Cell Mol Life Sci, 2007, vol. 64, 2351-2357. (PDF)
  18. Sokolowska, M., Kaus-Drobek, M., Czapinska, H., Tamulaitis, G., Szczepanowski, R. H., Urbanke, C., Siksnys, V. & Bochtler, M., Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA. J Mol Biol, 2007, vol. 369, 722-734. (PDF)
  19. Sukackaite, R., Lagunavicius, A., Stankevicius, K., Urbanke, C., Venclovas, C. & Siksnys, V., Restriction endonuclease BpuJI specific for the 5'-CCCGT sequence is related to the archaeal Holliday junction resolvase family. Nucleic Acids Res, 2007, vol. 35, 2377-2389. (PDF)
  20. Tamulaitis, G., Zaremba, M., Szczepanowski, R. H., Bochtler, M. & Siksnys, V., Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence. Nucleic Acids Res, 2007, vol. 35, 4792-4799. (PDF)
  21. Bochtler, M., Szczepanowski, R. H., Tamulaitis, G., Grazulis, S., Czapinska, H., Manakova, E. & Siksnys, V., Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease. EMBO J, 2006, vol. 25, 2219-2229. (PDF)
  22. Tamulaitiene, G., Jakubauskas, A., Urbanke, C., Huber, R., Grazulis, S. & Siksnys, V., The crystal structure of the rare-cutting restriction enzyme SdaI reveals unexpected domain architecture. Structure, 2006, vol. 14, 1389-1400. (PDF)
  23. Tamulaitis, G., Sasnauskas, G., Mucke, M. & Siksnys, V., Simultaneous binding of three recognition sites is necessary for a concerted plasmid DNA cleavage by EcoRII restriction endonuclease. J Mol Biol, 2006, vol. 358, 406-419. (PDF)
  24. Tamulaitis, G., Mucke, M. & Siksnys, V., Biochemical and mutational analysis of EcoRII functional domains reveals evolutionary links between restriction enzymes. FEBS Lett, 2006, vol. 580, 1665-1671. (PDF)
  25. Zaremba, M., Sasnauskas, G., Urbanke, C. & Siksnys, V., Allosteric communication network in the tetrameric restriction endonuclease Bse634I. J Mol Biol, 2006, vol. 363, 800-812. (PDF)
  26. Grazulis, S., Manakova, E., Roessle, M., Bochtler, M., Tamulaitiene, G., Huber, R. & Siksnys, V., Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proc Natl Acad Sci U S A, 2005, vol. 102, 15797-15802. (PDF)
  27. Zaremba, M., Sasnauskas, G., Urbanke, C. & Siksnys, V., Conversion of the tetrameric restriction endonuclease Bse634I into a dimer: oligomeric structure-stability-function correlations. J Mol Biol, 2005, vol. 348, 459-478. (PDF)

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