Biotechnologijos institutas yra  mokslinių tyrimų institucija, siekianti užtikrinti valstybės pažangą sparčiai besivystančiose gyvybės mokslų ir biotechnologijų srityse, plėtoti tarptautinio lygio molekulinės biotechnologijos tyrimus, skatinti tarpdisciplininius tyrimus bei mokslo ir verslo bendradarbiavimą

Bioinformatikos skyrius • Publikacijos

Spausdinti
2012
  • Venclovas Č. (2012) Methods for sequence-structure alignment. Methods Mol Biol, 857:55-82 [PubMed]
  • PDF
    2011
  • Timinskas K, Venclovas Č. (2011) The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III tau subunit. FEBS J, 278:3109-3118 [PubMed]
  • PDF
  • Kazlauskas D, Venclovas Č. (2011) Computational analysis of DNA replicases in double-stranded DNA viruses: relationship with the genome size. Nucleic Acids Res, 39:8291-305 [PubMed]
  • PDF
  • Olechnovič K, Margelevičius M, Venclovas Č. (2011) Voroprot: an interactive tool for the analysis and visualization of complex geometric features of protein structure. Bioinformatics, 27:723-724. [PubMed]
  • PDF
  • Laganeckas M, Margelevičius M, Venclovas Č. (2011) Identification of new homologs of PD-(D/E)XK nucleases by support vector machines trained on data derived from profile-profile alignments. Nucleic Acids Res, 39:1187-1196. [PubMed]
  • PDF
  • Barsky D, Laurence TA, Venclovas Č. (2011) How proteins slide on DNA. In Biophysics of DNA-protein interactions: From single molecules to biological systems, M.C. Williams and Maher, L.J. III, eds., Springer Science + Business Media, LLC, p.39-68. [Publisher link]
  • 2010

  • Warner DF, Ndwandwe DE, Abrahams GL, Kana BD, Machowski EE, Venclovas Č, Mizrahi V. (2010) Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. Proc Natl Acad Sci USA, 107:13093-13098. [PubMed]
  • PDF
  • Margelevičius M, Laganeckas M, and Venclovas Č. (2010) COMA server for protein distant homology search. Bioinformatics, 26:1905-1906. [PubMed]
  • PDF
  • Margelevičius M and Venclovas Č. (2010) Detection of distant evolutionary relationships between protein families using theory of sequence profile-profile comparison. BMC Bioinformatics, 11:89. [PubMed]
  • PDF
  • Zubrienė A, Gutkowska M, Matulienė J, Chaleckis R, Michailovienė V, Voroncova A, Venclovas Č, Zylicz A, Zylicz M, Matulis D. (2010) Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms. Biophys Chem, 152:153-163. [PubMed]
  • 2009

  • Venclovas Č and Margelevičius M. (2009) The use of automatic tools and human expertise in template-based modeling of CASP8 target proteins. Proteins, 77 Suppl 9:81-88. [ PubMed]
  • PDF
    2008
  • McCauley MJ, Shokri L, Sefcikova J, Venclovas Č, Beuning PJ, Williams M. (2008)  Distinct double- and single-stranded DNA binding of E. coli replicative DNA polymerase III alpha subunit. ACS Chem Biol, 3:577-587. [ PubMed]
  • PDF
  • Repšys V, Margelevičius M, and Venclovas Č. (2008) Re-searcher: a system for recurrent detection of homologous protein sequences. BMC Bioinformatics, 9:296. [PubMed]
  • PDF
    2007
  • Jurėnaitė-Urbanavičienė S, Šerkšnaitė J, Kriukienė E, Giedrienė J, Venclovas Č, Lubys A. (2007) Generation of DNA cleavage specificities of type II restriction endonucleases by reassortment of target recognition domains. Proc Natl Acad Sci USA, 104:10358-10363. [PubMed]
  • PDF
  • Sukackaite R, Lagunavicius A, Stankevicius K, Urbanke C, Venclovas Č, Siksnys V. (2007) Restriction endonuclease BpuJI specific for the 5'-CCCGT sequence is related to the archaeal Holliday junction resolvase family. Nucleic Acids Res., 35:2377-2389. [PubMed]
  • PDF
    2006
  • Shi G, Chang DY, Cheng CC, Guan X, Venclovas Č, Lu A-L. (2006) Physical and functional interactions between MutY homolog (MYH) and checkpoint proteins Rad9-Rad1-Hus1. Biochem J., 400:53-62. [PubMed]
  • PDF
    2005
  • Barsky D, Venclovas Č. (2005) DNA sliding clamps: just the right twist to load onto DNA. Curr Biol. 15:R989-R992. [PubMed]
  • PDF
  • Venclovas Č, Margelevičius M. (2005) Comparative modeling in CASP6 using consensus approach to template selection, sequence-structure alignment and structure assessment. Proteins, 61 Suppl 7:99-105. [PubMed]
  • PDF
  • Kryshtafovych A, Venclovas Č, Fidelis K, Moult J. (2005) Progress over the first decade of CASP experiments. Proteins, 61 Suppl 7:225-36. [PubMed]
  • Margelevičius M, Venclovas Č. (2005) PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability. BMC Bioinformatics, 6:185. [PubMed]
  • PDF
    2004
  • Daujotytė D, Serva S, Vilkaitis G, Merkienė E, Venclovas Č, Klimašauskas S. (2004) HhaI DNA methyltransferase uses the protruding Gln237 for active flipping of its target cytosine. Structure, 12:1047-55. [PubMed]
  • Venclovas Č, Ginalski K, Kang C. (2004) Sequence-structure mapping errors in the PDB: OB-fold domains. Protein Sci, 13:1594-1602. [PubMed]
  • PDF
    2003
  • Venclovas Č. (2003) Comparative modeling in CASP5: progress is evident, but alignment errors remain a significant hindrance. Proteins, 53, Suppl 6: 380-388. [PubMed]
  • PDF
  • Venclovas Č, Zemla A, Fidelis K, Moult J. (2003) Assessment of progress over the CASP experiments. Proteins, 53, Suppl 6:585-595. [PubMed]
  • PDF
  • Winthrop MD, DeNardo SJ, Albrecht H, Mirick GR, Kroger LA, Lamborn KR, Venclovas Č, Colvin ME, Burke PA, DeNardo GL. (2003) Selection and characterization of anti-MUC-1 scFvs intended for targeted therapy. Clinical Cancer Research, 9 (10 Pt 2):3845S-3853S. [PubMed]
  • PDF
    2002
  • Venclovas Č, Colvin ME, Thelen MP. (2002) Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process. Protein Sci., 11: 2403-2416. [PubMed]
  • PDF
  • Bitinaitė J, Mitkaitė G, Daukšaitė V, Jakubauskas A, Timinskas A, Vaišvila R, Lubys A, Janulaitis A. (2002) Evolutionary relationship of Alw26I, Eco31I and Esp3I, restriction endonucleases that recognise overlapping sequences. Mol Genet Genomics, 267:664-672. [PubMed]
  • Vilkaitis G, Lubys A, Merkienė E, Timinskas A, Janulaitis A, Klimašauskas S. (2002) Circular permutation of DNA cytosine-N4 methyltransferases: in vivo coexistence in the BcnI system and in vitro probing by hybrid formation. Nucleic Acids Res. 30:1547-1557 [PubMed]
  • PDF
    2001
  • Venclovas Č, Zemla A, Fidelis K, Moult J. (2001) Comparison of performance in successive CASP experiments. Proteins, Suppl. 5:163-170 [PubMed]

  • Venclovas Č. (2001) Comparative modeling of CASP4 target proteins: combining results of sequence search with three-dimensional structure assessment. Proteins, Suppl. 5:47-54. [PubMed]

  • Česnavičienė E, Petrušytė M, Kazlauskienė R, Manelienė Z, Timinskas A, Lubys A, Janulaitis A. (2001) Characterization of AloI, a restriction-modification system of a new type. J Mol Biol. 314:205-216. [PubMed]

  • Vitkutė J, Stankevičius K, Tamulaitienė G, Manelienė Z, Timinskas A, Berg DE, Janulaitis A. (2001) Specificities of eleven different DNA methyltransferases of Helicobacter pylori strain 26695. J Bacteriol. 183:443-450.[PubMed]

  • PDF

    2000
  • Ginalski K, Venclovas Č, Lesyng B, Fidelis K. (2000) Structure-based sequence alignment for the beta-trefoil sub-domain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site. FEBS Lett., 482:119-124. [PubMed]

  • Venclovas Č, Thelen M. (2000) Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes. Nucleic Acids Res., 28:2481-2493.[PubMed]

  • PDF

    1999
  • Venclovas Č, Ginalski K, Fidelis K. (1999) Addressing the issue of sequence-to-structure alignments in comparative modeling of CASP3 target proteins. Proteins, Suppl. 3:73-80. [PubMed]

  • Venclovas Č, Zemla A, Fidelis K, Moult J. (1999) Some measures of comparative performance in the three CASPs. Proteins, Suppl. 3: 231-237. [PubMed]

  • Zemla A, Venclovas Č, Moult J, Fidelis K. (1999) Processing and Analysis of CASP3 Protein Structure Predictions. Proteins, Suppl. 3:22-29. [PubMed]

  • Thelen M, Venclovas Č, Fidelis K. (1999) A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell, 96:769-770. [PubMed]

  • Zemla A, Venclovas Č, Fidelis K, Rost B. (1999) A modified definition of Sov, a segment based measure for protein secondary structure prediction assessment. Proteins, 34:220-223. [PubMed]