Biotechnologijos institutas yra  mokslinių tyrimų institucija, siekianti užtikrinti valstybės pažangą sparčiai besivystančiose gyvybės mokslų ir biotechnologijų srityse, plėtoti tarptautinio lygio molekulinės biotechnologijos tyrimus, skatinti tarpdisciplininius tyrimus bei mokslo ir verslo bendradarbiavimą

Publikacijos

Spausdinti

2010

 

    • Umbrasaite J, Schweighofer A, Kazanaviciute V, Magyar Z, Ayatollahi Z, Unterwurzacher V, Choopayak C, Boniecka J, Murray JA, Bogre L, Meskiene I. (2010) MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis. PLoS One 5(12):e15357. [PubMed]
    • Zvirbliene A, Pleckaityte M, Lasickiene R, Kucinskaite-Kodze I, Zvirblis G. (2010) Production and characterization of monoclonal antibodies against vaginolysin: mapping of a region critical for its cytolytic activity. Toxicon 56(1):19-28. [PubMed]
    • Saundh BK, Tibble S, Baker R, Sasnauskas K, Harris M, Hale A. (2010) Different patterns of BK and JC polyomavirus reactivation following renal transplantation. J Clin Pathol 63(8):714-8. [PubMed]
    • Wunderlich K, Juozapaitis M, Mänz B, Mayer D, Götz V, Zöhner A, Wolff T, Schwemmle M, Martin A. (2010) Limited compatibility of polymerase subunit interactions in influenza A and B viruses. J Biol Chem 285(22):16704-12. [PubMed]
    • Warrener L, Slibinskas R, Brown D, Sasnauskas K, Samuel D. (2010) Development and evaluation of a rapid immunochromatographic test for mumps-specific IgM in oral fluid specimens and use as a matrix for preserving viral nucleic acid for RT-PCR. J Med Virol 82(3):485-93. [PubMed]
    • Razanskas R., Sasnauskas K. (2010) Interaction of hepatitis B virus core protein with human GIPC1. Arch Virol 155(2):247-50. [PubMed]
    • Emuzyte R., Firantiene R., Petraityte R., Sasnauskas K. (2010) Human rhinoviruses, allergy, and asthma: a clinical approach. Medicina (Kaunas) 45(11):839-47. [PubMed]
    • Zvirbliene A., Kucinskaite-Kodze I., Juozapaitis M., Lasickiene R., Gritenaite D., Russell G., Bingham J., Michalski W.P., Sasnauskas K. (2010) Novel monoclonal antibodies against Menangle virus nucleocapsid protein. Arch Virol 155(1):13-8. [PubMed]
    • Schmidt-Chanasit J., Essbauer S., Petraityte R., Yoshimatsu K., Tackmann K., Conraths F.J., Sasnauskas K., Arikawa J., Thomas A., Pfeffer M., Scharninghausen J.J., Splettstoesser W., Wenk M., Heckel G., Ulrich R.G. (2010) Extensive host sharing of central European Tula virus. J Virol 84(1):459-74. [PubMed]

2009

 

    • Razanskas R., Sasnauskas K. (2009) A novel human protein is able to interact with hepatitis B virus core deletion mutant but not with the wild-type protein. Virus Res 146(1-2):130-4. [PubMed]
    • Petraityte R., Tamosiunas P.L., Juozapaitis M., Zvirbliene A., Sasnauskas K., Shiell B., Russell G., Bingham J., Michalski W.P. (2009) Generation of Tioman virus nucleocapsid-like particles in yeast Saccharomyces cerevisiae. Virus Res 145(1):92-6. [PubMed]
    • Valiunas D., Jomantiene R., Ivanauskas A., Abraitis R., Staniene G., Zhao Y. and Davis R. E. (2009) First Report of a New Phytoplasma Subgroup, 16SrIII-T, Associated with Decline Disease Affecting Sweet and Sour Cherry Trees. Plant Dis. 93(5), 550.
    • Zvirbliene A., Sezaite I., Pleckaityte M., Kucinskaite-Kodze I., Juozapaitis M. and Sasnauskas K. (2009) Mapping of an antigenic site on the nucleocapsid protein of human parainfluenza virus type 3. Viral Immunol 22(3), 181-8. [PubMed]

 

2008

 

    • Dorn D.C., Lawatscheck R., Zvirbliene A., Aleksaite E., Pecher G., Sasnauskas K., Ozel M., Raftery M., Schonrich G., Ulrich R.G. and Gedvilaite A. (2008) Cellular and humoral immunogenicity of hamster polyomavirus-derived virus-like particles harboring a mucin 1 cytotoxic T-cell epitope. Viral Immunol 21(1), 12-27. [PubMed]
    • Skrastina D., Bulavaite A., Sominskaya I., Kovalevska L., Ose V., Priede D., Pumpens P. and Sasnauskas K. (2008) High immunogenicity of a hydrophilic component of the hepatitis B virus preS1 sequence exposed on the surface of three virus-like particle carriers. Vaccine 26(16), 1972-81. [PubMed]
    • Juozapaitis M., Zvirbliene A., Kucinskaite I., Sezaite I., Slibinskas R., Coiras M., de Ory Manchon F., Lopez-Huertas M.R., Perez-Brena P., Staniulis J., Narkeviciute I. and Sasnauskas K. (2008) Synthesis of recombinant human parainfluenza virus 1 and 3 nucleocapsid proteins in yeast Saccharomyces cerevisiae. Virus Res. 133(2), 178-86. [PubMed]
    • Ramirez P., Hernandez E., Mora F., Abraitis R. and Hammond R.W. (2008) Limited geographic distribution of beet pseudo-yellows virus in Costa Rican cucurbits. J. Plant Pathol. 90(2), 331-5.
    • Abraitiene A., Zhao Y. and Hammond R. (2008) Nuclear targeting by fragmentation of the Potato spindle tuber viroid genome. Biochem Biophys Res Commun. 368(3), 470-5. [PubMed]
    • Verschoor E.J., Niphuis H., Fagrouch Z., Christian P., Sasnauskas K., Pizarro M.C. and Heeney J.L. (2008) Seroprevalence of SV40-like polyomavirus infections in captive and free-ranging macaque species. J Med Primatol 37(4), 196-201. [PubMed]
    • Petraityte R., Yang H., Hunjan R., Razanskiene A., Dhanilall P., Ulrich R.G., Sasnauskas K. and Jin L. (2008) Development and evaluation of serological assays for detection of Hantaanvirus-specific antibodies in human sera using yeast-expressed nucleocapsid protein. J Virol Methods 148(1-2), 89-95. [PubMed]
    • Antoniukas L., Grammel H., Sasnauskas K. and Reichl U. (2008) Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant Saccharomyces cerevisiae. Biotechnol Lett 30(3), 415-20. [PubMed]

 

2007

 

    • Petraityte R., Jin L., Hunjan R., Razanskiene A., Zvirbliene A. and Sasnauskas K. (2007) Use of Saccharomyces cerevisiae-expressed recombinant nucleocapsid protein to detect Hantaan virus-specific immunoglobulin G (IgG) and IgM in oral fluid. Clin Vaccine Immunol 14(12), 1603-8. [PubMed]
    • Kucinskaite I., Juozapaitis M., Serva A., Zvirbliene A., Johnson N., Staniulis J., Fooks A.R., Muller T., Sasnauskas K. and Ulrich R.G. (2007) Antigenic characterisation of yeast-expressed lyssavirus nucleoproteins. Virus Genes 35(3), 521-9. [PubMed]
    • Dargevicius A., Petraityte R., Sribikiene B., Sileikiene E., Razukeviciene L., Ziginskiene E., Vorobjoviene R., Razanskiene A., Sasnauskas K., Bumblyte I.A. and Kuzminskis V. (2007) [Prevalence of antibodies to hantavirus among hemodialysis patients with end-stage renal failure in Kaunas and its district]. Medicina (Kaunas) 43 Suppl 1, 72-6. [PubMed]
    • Lundstig A., Stattin P., Persson K., Sasnauskas K., Viscidi R.P., Gislefoss R.E. and Dillner J. (2007) No excess risk for colorectal cancer among subjects seropositive for the JC polyomavirus. Int J Cancer 121(5), 1098-102. [PubMed]
    • Essbauer S.S., Schmidt-Chanasit J., Madeja E.L., Wegener W., Friedrich R., Petraityte R., Sasnauskas K., Jacob J., Koch J., Dobler G., Conraths F.J., Pfeffer M., Pitra C. and Ulrich R.G. (2007) Nephropathia epidemica in metropolitan area, Germany. Emerg Infect Dis 13(8), 1271-3. [PubMed]
    • Lawatscheck R., Aleksaite E., Schenk J.A., Micheel B., Jandrig B., Holland G., Sasnauskas K., Gedvilaite A. and Ulrich R.G. (2007) Chimeric polyomavirus-derived virus-like particles: the immunogenicity of an inserted peptide applied without adjuvant to mice depends on its insertion site and its flanking linker sequence. Viral Immunol 20(3), 453-60. [PubMed]
    • Juozapaitis M., Serva A., Kucinskaite I., Zvirbliene A., Slibinskas R., Staniulis J., Sasnauskas K., Shiell B.J., Bowden T.R. and Michalski W.P. (2007) Generation of menangle virus nucleocapsid-like particles in yeast Saccharomyces cerevisiae. J Biotechnol 130(4), 441-7. [PubMed]
    • Juozapaitis M., Serva A., Zvirbliene A., Slibinskas R., Staniulis J., Sasnauskas K., Shiell B.J., Wang L.F. and Michalski W.P. (2007) Generation of henipavirus nucleocapsid proteins in yeast Saccharomyces cerevisiae. Virus Res 124(1-2), 95-102. [PubMed]
    • Zvirbliene A., Kucinskaite I., Sezaite I., Samuel D. and Sasnauskas K. (2007) Mapping of B cell epitopes in measles virus nucleocapsid protein. Arch Virol 152(1), 25-39. [PubMed]

 

2006

 

    • Meisel H., Wolbert A., Razanskiene A., Marg A., Kazaks A., Sasnauskas K., Pauli G., Ulrich R. and Kruger D.H. (2006) Development of novel immunoglobulin G (IgG), IgA, and IgM enzyme immunoassays based on recombinant Puumala and Dobrava hantavirus nucleocapsid proteins. Clin Vaccine Immunol 13(12), 1349-57. [PubMed]
    • Gedvilaite A., Dorn D.C., Sasnauskas K., Pecher G., Bulavaite A., Lawatscheck R., Staniulis J., Dalianis T., Ramqvist T., Schonrich G., Raftery M.J. and Ulrich R. (2006) Virus-like particles derived from major capsid protein VP1 of different polyomaviruses differ in their ability to induce maturation in human dendritic cells. Virology 354(2), 252-60. [PubMed]
    • Zielonka A., Gedvilaite A., Ulrich R., Luschow D., Sasnauskas K., Muller H. and Johne R. (2006) Generation of virus-like particles consisting of the major capsid protein VP1 of goose hemorrhagic polyomavirus and their application in serological tests. Virus Res 120(1-2), 128-37. [PubMed]
    • Gedvilaite A., Aleksaite E., Staniulis J., Ulrich R. and Sasnauskas K. (2006) Size and position of truncations in the carboxy-terminal region of major capsid protein VP1 of hamster polyomavirus expressed in yeast determine its assembly capacity. Arch Virol 151(9), 1811-25. [PubMed]
    • Zvirbliene A., Samonskyte L., Gedvilaite A., Voronkova T., Ulrich R. and Sasnauskas K. (2006) Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles. J Immunol Methods 311(1-2), 57-70. [PubMed]
    • Freivalds J., Dislers A., Ose V., Skrastina D., Cielens I., Pumpens P., Sasnauskas K. and Kazaks A. (2006) Assembly of bacteriophage Qbeta virus-like particles in yeast Saccharomyces cerevisiae and Pichia pastoris. J Biotechnol 123(3), 297-303. [PubMed]

 

2005

 

    • Glebe D., Urban S., Knoop E.V., Cag N., Krass P., Grun S., Bulavaite A., Sasnauskas K. and Gerlich W.H. (2005) Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes. Gastroenterology 129(1), 234-45. [PubMed]
    • Lundstig A., Eliasson L., Lehtinen M., Sasnauskas K., Koskela P. and Dillner J. (2005) Prevalence and stability of human serum antibodies to simian virus 40 VP1 virus-like particles. J Gen Virol 86(Pt 6), 1703-8. [PubMed]
    • Sandmann S., Meisel H., Razanskiene A., Wolbert A., Pohl B., Kruger D.H., Sasnauskas K. and Ulrich R. (2005) Detection of human hantavirus infections in Lithuania. Infection 33(2), 66-72. [PubMed]
    • Juozapaitis M., Slibinskas R., Staniulis J., Sakaguchi T. and Sasnauskas K. (2005) Generation of Sendai virus nucleocapsid-like particles in yeast. Virus Res 108(1-2), 221-4. [PubMed]
    • Stolt A., Kjellin, M., Sasnauskas K., Luostarinen T., Koskela P., Lehtinen M. and Dillner J. (2005) Maternal human polyomavirus infection and risk of neuroblastoma in the child. Int J Cancer 113(3), 393-6. [PubMed]

 

2004

 

    • Bartkeviciute D. and Sasnauskas, K. (2004) Disruption of the MNN10 gene enhances protein secretion in Kluyveromyces lactis and Saccharomyces cerevisiae. FEMS Yeast Res 4(8), 833-40. [PubMed]
    • Razanskiene A., Schmidt J., Geldmacher A., Ritzi A., Niedrig M., Lundkvist A., Kruger D.H., Meisel H., Sasnauskas K. and Ulrich R. (2004) High yields of stable and highly pure nucleocapsid proteins of different hantaviruses can be generated in the yeast Saccharomyces cerevisiae. J Biotechnol 111(3), 319-33. [PubMed]
    • Gedvilaite A., Zvirbliene A., Staniulis J., Sasnauskas K., Kruger D.H. and Ulrich R. (2004) Segments of puumala hantavirus nucleocapsid protein inserted into chimeric polyomavirus-derived virus-like particles induce a strong immune response in mice. Viral Immunol 17(1), 51-68. [PubMed]
    • Slibinskas R., Samuel D., Gedvilaite A., Staniulis J. and Sasnauskas K. (2004) Synthesis of the measles virus nucleoprotein in yeast Pichia pastoris and Saccharomyces cerevisiae. J Biotechnol 107(2), 115-24. [PubMed]

 

2003

 

    • Samuel D., Sasnauskas K., Jin L., Gedvilaite A., Slibinskas R., Beard S., Zvirbliene A., Oliveira S.A., Staniulis J., Cohen B. and Brown D. (2003) Development of a measles specific IgM ELISA for use with serum and oral fluid samples using recombinant measles nucleoprotein produced in Saccharomyces cerevisiae. J Clin Virol 28(2), 121-9. [PubMed]
    • Stolt A., Sasnauskas K., Koskela P., Lehtinen M. and Dillner J. (2003) Seroepidemiology of the human polyomaviruses. J Gen Virol 84(Pt 6), 1499-504. [PubMed]
    • Slibinskas R., Zvirbliene A., Gedvilaite A., Samuel D., Jin L., Beard S., Staniulis J. and Sasnauskas K. (2003) Synthesis of mumps virus nucleocapsid protein in yeast Pichia pastoris. J Biotechnol 103(1), 43-9. [PubMed]
    • Knowles W.A. and Sasnauskas K. (2003) Comparison of cell culture-grown JC virus (primary human fetal glial cells and the JCI cell line) and recombinant JCV VP1 as antigen for the detection of anti-JCV antibody by haemagglutination inhibition. J Virol Methods 109(1), 47-54. [PubMed]
    • Bartkeviciute D. and Sasnauskas K. (2003) Studies of yeast Kluyveromyces lactis mutations conferring super-secretion of recombinant proteins. Yeast 20(1), 1-11. [PubMed]

 

2002

 

    • Sasnauskas K., Bulavaite A., Hale A., Jin L., Knowles W.A., Gedvilaite A., Dargeviciute A., Bartkeviciute D., Zvirbliene A., Staniulis J., Brown D.W. and Ulrich R. (2002) Generation of recombinant virus-like particles of human and non-human polyomaviruses in yeast Saccharomyces cerevisiae. Intervirology 45(4-6), 308-17. [PubMed]
    • Voronkova T., Grosch A., Kazaks A., Ose V., Skrastina D., Sasnauskas K., Jandrig B., Arnold W., Scherneck S., Pumpens P. and Ulrich R. (2002) Chimeric bacteriophage fr virus-like particles harboring the immunodominant C-terminal region of hamster polyomavirus VP1 induce a strong VP1-specific antibody response in rabbits and mice. Viral Immunol 15(4), 627-43. [PubMed]
    • Dargeviciute A., Brus Sjolander K., Sasnauskas K., Kruger D.H., Meisel H., Ulrich R. and Lundkvist A. (2002) Yeast-expressed Puumala hantavirus nucleocapsid protein induces protection in a bank vole model. Vaccine 20(29-30), 3523-31. [PubMed]
    • Hale A.D., Bartkeviciute D., Dargeviciute A., Jin L., Knowles W., Staniulis J., Brown D.W. and Sasnauskas K. (2002) Expression and antigenic characterization of the major capsid proteins of human polyomaviruses BK and JC in Saccharomyces cerevisiae. J Virol Methods 104(1), 93-8. [PubMed]
    • Borkhsenius A.S., Sasnauskas K., Gedvilaite A. and Inge-Vechtomov S.G. (2002) [Chimeric yeast prions with unstable inheritance]. Genetika 38(3), 300-5. [PubMed]
    • Pumpens P., Razanskas R., Pushko P., Renhof R., Gusars I., Skrastina D., Ose V., Borisova G., Sominskaya I., Petrovskis I., Jansons J. and Sasnauskas K. (2002) Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes. Intervirology 45(1), 24-32. [PubMed]
    • Samuel D., Sasnauskas K., Jin L., Beard S., Zvirbliene A., Gedvilaite A. and Cohen B. (2002) High level expression of recombinant mumps nucleoprotein in Saccharomyces cerevisiae and its evaluation in mumps IgM serology. J Med Virol 66(1), 123-30. [PubMed]

 

2000

 

    • Gedvilaite A., Frommel C., Sasnauskas K., Micheel B., Ozel M., Behrsing O., Staniulis J., Jandrig B., Scherneck S. and Ulrich R. (2000) Formation of immunogenic virus-like particles by inserting epitopes into surface-exposed regions of hamster polyomavirus major capsid protein. Virology 273(1), 21-35. [PubMed]
    • Schaffrath R., Sasnauskas K. and Meacock P.A. (2000) Use of gene shuffles to study the cytoplasmic transcription system operating on Kluyveromyces lactis linear DNA plasmids. Enzyme Microb Technol 26(9-10), 664-670. [PubMed]
    • Bartkeviciute D., Siekstele R. and Sasnauskas K. (2000) Heterologous expression of the Kluyveromyces marxianus endopolygalacturonase gene (EPG1) using versatile autonomously replicating vector for a wide range of host. Enzyme Microb Technol 26(9-10), 653-656. [PubMed]

 

1999

 

    • Sasnauskas K., Buzaite O., Vogel F., Jandrig B., Razanskas R., Staniulis J., Scherneck S., Kruger D.H. and Ulrich R. (1999) Yeast cells allow high-level expression and formation of polyomavirus-like particles. Biol Chem 380(3), 381-6. [PubMed]
    • Siekstele R., Bartkeviciute D. and Sasnauskas K. (1999) Cloning, targeted disruption and heterologous expression of the Kluyveromyces marxianus endopolygalacturonase gene (EPG1). Yeast 15(4), 311-22. [PubMed]

 

1994

 

    • Gedvilaite A. and Sasnauskas K. (1994) Control of the expression of the ADE2 gene of the yeast Saccharomyces cerevisiae. Curr Genet 25(6), 475-9. [PubMed]

 

1992

 

    • Sasnauskas K., Jomantiene R., Januska A., Lebediene E., Lebedys J. and Janulaitis A. (1992) Cloning and analysis of a Candida maltosa gene which confers resistance to formaldehyde in Saccharomyces cerevisiae. Gene 122(1), 207-11. [PubMed]
    • Sasnauskas K., Jomantiene R., Lebediene E., Lebedys J., Januska A. and Janulaitis A. (1992) Cloning and sequence analysis of a Candida maltosa gene which confers resistance to cycloheximide. Gene 116(1), 105-8. [PubMed]
    • Sasnauskas K., Jomantiene R., Lebediene E., Lebedys J., Januska A. and Janulaitis A. (1992) Molecular cloning and analysis of autonomous replicating sequence of Candida maltosa. Yeast 8(4), 253-9. [PubMed]

 

1991

 

    • Myasnikov A.N., Sasnauskas K.V., Janulaitis A.A. and Smirnov M.N. (1991) The Saccharomyces cerevisiae ADE1 gene: structure, overexpression and possible regulation by general amino acid control. Gene 109(1), 143-7. [PubMed]
    • Sasnauskas K., Jomantiene R., Geneviciute E., Januska A. and Lebedys J. (1991) Molecular cloning of the Candida maltosa ADE1 gene. Gene 107(1), 161-4. [PubMed]

 

1988

 

    • Ianushka A.P., Sasnauskas K.V. and Ianulaitis A.A. (1988) [Cloning of the gene of Saccharomyces cerevisiae yeasts that determines resistance to the toxic action of cadmium ions]. Genetika 24(5), 773-80. [PubMed]

 

1987

 

    • Sasnauskas K.V., Giadvilaite A.A. and Ianulaitis A.A. (1987) [Cloning of the ADE2 gene of Saccharomyces cerevisiae and localization of the ARS-sequence]. Genetika 23(7), 1141-8. [PubMed]
    • Gedminene G.K., Sasnauskas K.V. and Ianulaitis A.A. (1987) [Site of integration of IS1-element responsible for expression of the yeast ADE1 gene in Escherichia coli]. Genetika 23(9), 1702-4. [PubMed]

 

1986

 

    • Sasnauskas K.V., Gedminene G.K., Markiavichius A.I., Naktinis V.I. and Ianulaitis A.A. (1986) [Cloning and physical mapping of the ADE1 gene of the yeast Saccharomyces cerevisiae]. Genetika 22(4), 549-56. [PubMed]
    • Miasnikov A.N., Plavnik Iu A., Sasnauskas K.V., Gedminene G.K. and Ianulaitis A.A. (1986) [Nucleotide sequence of the ADE 1 gene of the yeast Saccharomyces cerevisiae]. Bioorg Khim 12(4), 555-8. [PubMed]



Tarptautiniai patentai

 

    • Žvirblienė A., Gedvilaitė A., Ulrich R. and Sasnauskas K. Process for the production of monoclonal antibodies using chimeric VLPs. Patent international publication date 2006.10.19. International publication numbers WO2006/108658.
    • Ulrich R, Dargevičiūtė A, Sasnauskas K and Lundkvist A. Vaccines containing recombinant hantavirus proteins, methods for producing said vaccines and their use. WO0238174A2. 16/05/2002.
    • Šiekstelė R., Bartkevičiūtė D., Sasnauskas K., Dohner L., Becher D. and Salim S. Regulatorische Sequenzen und Expressionkassetten fur Hefen. Deutsches Patent und Markenam. DE 199 43 383 A1. 14.04.2001
    • Becher D.,Šiekštelė R., Bartkevičiūtė D., Sasnauskas K., Dohner L. and Salim S. Regulatory sequences and expression cassettes for yeasts. International patent classification C12N 15/56. WO 01/20005 A1. 22.03.2001.
    • Scherneck S., Sasnauskas K. and Ulrich R. Verfahren zur Gewinnung von virusahnlichen Partikeln auf der Basis von Polyomaveren. DE 197 50 220 A1. 20.05.1999.

 

 

 

 

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